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KMID : 0614720180610010057
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Journal of Korean Medical Association
2018 Volume.61 No. 1 p.57 ~ p.61
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Pharmacological treatment of chronic constipation: focused on oral laxatives
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Shin Jeong-Eun
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Abstract
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Chronic constipation is a common functional gastrointestinal disorder that may have a significant impact on the quality of life of affected individuals. If dietary and lifestyle modifications are not successful, pharmacological interventions should be used to manage chronic constipation. The first-line conventional laxatives include bulk-forming, osmotic, and stimulant laxatives. If chronic constipation is refractory to conventional laxatives, prucalopride should be considered. The choice of a laxative should be made based on a consideration of the treatment duration, dosing schedule, type of agent, effects, and side effects of the agent, as well as cost-effectiveness. An individualized approach is needed according to the patient's underlying disease and clinical condition.
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KEYWORD
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Constipation, Laxatives, Therapeutics
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